Post by Ian Thomas on Dec 12, 2023 13:18:32 GMT 10
An interesting idea. We live short lives because dinosaurs hunted our distant ancestors ...
The longevity bottleneck hypothesis: Could dinosaurs have shaped ageing in present-day mammals?
Magalhães, J. P. de. (2023). BioEssays, 2300098.
doi.org/10.1002/bies.202300098
The evolution and biodiversity of ageing have long fascinated scientists and the public alike. While mammals, including long-lived species such as humans, show a marked ageing process, some species of reptiles and amphibians exhibit very slow and even the absence of ageing phenotypes.
How can reptiles and other vertebrates age slower than mammals? Herein, I propose that evolved during the rule of the dinosaurs left a lasting legacy in mammals.
For over 100 million years when dinosaurs were the dominant predators, mammals were generally small, nocturnal, and short-lived. My hypothesis is that such a long evolutionary pressure on early mammals for rapid reproduction led to the loss or inactivation of genes and pathways associated with long life.
I call this the ‘longevity bottleneck hypothesis’, which is further supported by the absence in mammals of regenerative traits. Although mammals, such as humans, can evolve long lifespans, they do so under constraints dating to the dinosaur era.
Magalhães, J. P. de. (2023). BioEssays, 2300098.
doi.org/10.1002/bies.202300098
The evolution and biodiversity of ageing have long fascinated scientists and the public alike. While mammals, including long-lived species such as humans, show a marked ageing process, some species of reptiles and amphibians exhibit very slow and even the absence of ageing phenotypes.
How can reptiles and other vertebrates age slower than mammals? Herein, I propose that evolved during the rule of the dinosaurs left a lasting legacy in mammals.
For over 100 million years when dinosaurs were the dominant predators, mammals were generally small, nocturnal, and short-lived. My hypothesis is that such a long evolutionary pressure on early mammals for rapid reproduction led to the loss or inactivation of genes and pathways associated with long life.
I call this the ‘longevity bottleneck hypothesis’, which is further supported by the absence in mammals of regenerative traits. Although mammals, such as humans, can evolve long lifespans, they do so under constraints dating to the dinosaur era.
